2019-11-04
- Verena Kutschera
When?
Monday, 4 November 2019
13.00 - 14.00 h
Where?
Stockholm - Scilifelab Gamma 7, Berlin
Virtual conference - SciLifeLab@vconf.kth.se (how to connect)
Which paper are we discussing?
Bourque, Guillaume, Kathleen H. Burns, Mary Gehring, Vera Gorbunova, Andrei Seluanov, Molly Hammell, Michaël Imbeault, et al. 2018. “Ten Things You Should Know about Transposable Elements.” Genome Biology 19 (1): 199. https://doi.org/10.1186/s13059-018-1577-z.
I chose this paper because transposable elements make up large proportions of the genome and are getting more and more attention due to their potential functional relevance and usefulness as evolutionary markers. I will present the paper and talk briefly about some repeat analyses I've been doing for different projects and how these could be improved by manual curation of repeat libraries.
Abstract
Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.
Who is presenting?
Verena