2021-03-05

When?

Friday, 5 March 2021

10.00 - 11.00 h

Where?

https://stockholmuniversity.zoom.us/j/62208705509

Which paper are we discussing?

We will continue with the presentation from last journal club (https://wabi-wiki.scilifelab.se/x/Z4uYBQ), focusing on PCA and the curse of dimensionality in genomics data.

The presentation is followed by a discussion on PCA in population genomics. Here is some recommended literature for the discussion:

1. Patterson, Nick et al 2006. 'Population Structure and Eigenanalysis' PLoS Genetics  2(12): e190. https://doi.org/10.1371/journal.pgen.0020190

2. Björklund, Mats. 2019. ‘Be Careful with Your Principal Components’. Evolution 73 (10): 2151–58. https://doi.org/10.1111/evo.13835

3. McVean, Gil. 2009. ‘A Genealogical Interpretation of Principal Components Analysis’. PLOS Genetics 5 (10): e1000686. https://doi.org/10.1371/journal.pgen.1000686

Who is presenting?

Nikolay

Presentation: Misleading_PCA.ppt

Notes