When?

Friday, 13 March 2020

10.00 - 11.00 h

Where?

Stockholm - Gamma 7, meeting room Helsingfors

Uppsala - TBA

Virtual conference - SciLifeLab@vconf.kth.se (how to connect)

Which paper are we discussing?

A method for genome-wide genealogy estimation for thousands of samples Leo Speidel, Marie Forest, Sinan Shi, and Simon R. Myers (https://www.nature.com/articles/s41588-019-0484-x). See also comment by Kelley Harris in same issue (From a database of genomes to a forest of evolutionary trees, https://www.nature.com/articles/s41588-019-0492-x)

The paper discusses the Relate method which estimates whole-genome genealogies. In particular, this means estimating genealogies across all loci in a sample of genomes. This is a time-consuming effort, where previous methods (e.g. ARGweaver by Rasmussen et al) could only analyze a handful of loci. Relate achieves a considerable speedup by employing various heuristics, enabling the analysis of whole-genome data for thousands of individuals. The method provides greater power for inference of natural selection and to characterize recent demographic history.

Who is presenting?

Per

Notes

Pdf version of presentation: relate.pdf

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